SIBsim4 0.14 review

SIBsim4 project is based on sim4, which is a program designed to align an expressed DNA sequence with a genomic sequence, allowing fo

License: GPL (GNU General Public License) File size: 0K Developer: Christian Iseli

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SIBsim4 project is based on sim4, which is a program designed to align an expressed DNA sequence with a genomic sequence, allowing for introns.

SIBsim4 is an extensive rewrite of the sim4 program to improve execution speed and provide more informative output.

The name was chosen to denote the fact the SIBsim4 is a derivative work from sim4. SIB stands for the Swiss Institute of Bioinformatics. Some code modifications were written by Claudio Lottaz, while working at SIB.

SIBsim4 is currently developed and maintained by Christian Iseli, from the Ludwig Institute for Cancer Research LICR, Information Technology Office in Lausanne. LICR is a SIB partner.

Here are some key features of "SIBsim4":
speed improvement
allow large, chromosome scale, DNA sequences to be used
provide more detailed output about splice types
provide more detailed output about polyA sites
misc code cleanups and fixes

What's New in This Release:
Introduce two new options (-c and -f) to provide full control over how results are filtered.
This allows better detection of duplicated genes, where duplicates are not complete or well preserved.